7LL4

High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-114.

Summary for 7LL4

• Entry DOI: 10.2210/pdb7ll4/pdb
• Descriptor: Tyrosine-protein kinase JAK2, {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile (3 entities in total)
• Functional Keywords: rheumatoid arthritis, innate immuninity, adaptive immunity, myeloproliferative neoplasms, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 35522.57

Authors

Karim, M.R.,Schonbrunn, E. (deposition date: 2021-02-03, release date: 2022-01-12, Last modification date: 2023-11-15)

• Primary citation: Karim, M.R.,Schonbrunn, E.; High-resolution crystal structure of human Janus Kinase 2 kinase domain (JH1) bound to PN5-114.; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.31 Å)