7LL4

High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-114.

7LL4 の概要

• エントリーDOI: 10.2210/pdb7ll4/pdb
• 分子名称: Tyrosine-protein kinase JAK2, {1-(ethylsulfonyl)-3-[4-(2-{[3-fluoro-4-(1-methylpiperidin-4-yl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile (3 entities in total)
• 機能のキーワード: rheumatoid arthritis, innate immuninity, adaptive immunity, myeloproliferative neoplasms, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35522.57

構造登録者

Karim, M.R.,Schonbrunn, E. (登録日: 2021-02-03, 公開日: 2022-01-12, 最終更新日: 2023-11-15)

• 主引用文献: Karim, M.R.,Schonbrunn, E.; High-resolution crystal structure of human Janus Kinase 2 kinase domain (JH1) bound to PN5-114.; To Be Published,

実験手法

X-RAY DIFFRACTION (1.31 Å)