7LKB

Crystal structure of PfCSP peptide 21 with vaccine-elicited human anti-malaria antibody m42.127

Summary for 7LKB

Entry DOI	10.2210/pdb7lkb/pdb
Descriptor	m42.127 Fab heavy Chain, m42.127 Fab light chain, Circumsporozoite protein, ... (5 entities in total)
Functional Keywords	malaria, csp, junction region, antibody, m42.127, immune system, immune system-antigen complex, immune system/antigen
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	102239.75
Authors	Xu, K.,Kwong, P.D. (deposition date: 2021-02-02, release date: 2021-12-15, Last modification date: 2023-10-18)
Primary citation	Kratochvil, S.,Shen, C.H.,Lin, Y.C.,Xu, K.,Nair, U.,Da Silva Pereira, L.,Tripathi, P.,Arnold, J.,Chuang, G.Y.,Melzi, E.,Schon, A.,Zhang, B.,Dillon, M.,Bonilla, B.,Flynn, B.J.,Kirsch, K.H.,Kisalu, N.K.,Kiyuka, P.K.,Liu, T.,Ou, L.,Pancera, M.,Rawi, R.,Reveiz, M.,Seignon, K.,Wang, L.T.,Waring, M.T.,Warner, J.,Yang, Y.,Francica, J.R.,Idris, A.H.,Seder, R.A.,Kwong, P.D.,Batista, F.D. Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies. Immunity, 54:2859-2876.e7, 2021 Cited by PubMed: 34788599 DOI: 10.1016/j.immuni.2021.10.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation