7LJU

Porcine Dihydropyrimidine Dehydrogenase (DPD) crosslinked with 5-Ethynyluracil (5EU)

7LJU の概要

• エントリーDOI: 10.2210/pdb7lju/pdb
• 分子名称: Dihydropyrimidine dehydrogenase [NADP(+)], IRON/SULFUR CLUSTER, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total)
• 機能のキーワード: dihydropyrimidine dehydrogenase, dpd, dehydrogenase, 5-ethynyluracil, 5eu, inhibitor, inactivator, crosslinking, flavoprotein
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 460533.31

構造登録者

Butrin, A.,Forouzesh, D.,Beaupre, B.,Wawrzak, Z.,Liu, D.,Moran, G. (登録日: 2021-01-30, 公開日: 2021-04-07, 最終更新日: 2023-10-18)

• 主引用文献: Forouzesh, D.C.,Beaupre, B.A.,Butrin, A.,Wawrzak, Z.,Liu, D.,Moran, G.R.; The Interaction of Porcine Dihydropyrimidine Dehydrogenase with the Chemotherapy Sensitizer: 5-Ethynyluracil.; Biochemistry, 60:1120-1132, 2021; PubMed: 33755421; DOI: 10.1021/acs.biochem.1c00096

実験手法

X-RAY DIFFRACTION (1.87 Å)