7LIR

Structure of the invertebrate ALK GRD

7LIR の概要

• エントリーDOI: 10.2210/pdb7lir/pdb
• 分子名称: ALK tyrosine kinase receptor homolog scd-2, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: alk, anaplastic lymphoma kinase, grd, glycine rich domain, pole, poly-glycine extension, pxl, poly-glycine extension loops, neuroblastoma, cancer, receptor, kinase, oncogene, aug, augmentor, alkal, alk and ltk activating ligand, fam150, signaling protein
• 由来する生物種: Caenorhabditis elegans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 81456.97

構造登録者

Stayrook, S.,Li, T.,Klein, D.E. (登録日: 2021-01-27, 公開日: 2021-11-24, 最終更新日: 2021-12-15)

• 主引用文献: Li, T.,Stayrook, S.E.,Tsutsui, Y.,Zhang, J.,Wang, Y.,Li, H.,Proffitt, A.,Krimmer, S.G.,Ahmed, M.,Belliveau, O.,Walker, I.X.,Mudumbi, K.C.,Suzuki, Y.,Lax, I.,Alvarado, D.,Lemmon, M.A.,Schlessinger, J.,Klein, D.E.; Structural basis for ligand reception by anaplastic lymphoma kinase.; Nature, 600:148-152, 2021; PubMed: 34819665; DOI: 10.1038/s41586-021-04141-7

実験手法

X-RAY DIFFRACTION (2.6 Å)