7LES
Acanthamoeba castellanii CYP51 (AcCYP51)-Imidazole complex
Summary for 7LES
| Entry DOI | 10.2210/pdb7les/pdb |
| Descriptor | Obtusifoliol 14alphademethylase, putative, PROTOPORPHYRIN IX CONTAINING FE, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
| Functional Keywords | cyp51, ergosterol biosynthesis, acanthamoeba, 14-alpha-demethylase, oxidoreductase |
| Biological source | Acanthamoeba castellanii str. Neff |
| Total number of polymer chains | 4 |
| Total formula weight | 213306.38 |
| Authors | Sharma, V.,Podust, L.M. (deposition date: 2021-01-15, release date: 2021-12-22, Last modification date: 2023-10-18) |
| Primary citation | Nienhaus, K.,Sharma, V.,Nienhaus, G.U.,Podust, L.M. Homodimerization Counteracts the Detrimental Effect of Nitrogenous Heme Ligands on the Enzymatic Activity of Acanthamoeba castellanii CYP51. Biochemistry, 61:1363-1377, 2022 Cited by PubMed: 35730528DOI: 10.1021/acs.biochem.2c00198 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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