7LEO

C1B domain of Protein kinase C in complex with diacylglycerol-lactone (AJH-836) and 1,2-diheptanoyl-sn-glycero-3-phosphocholine

Summary for 7LEO

Entry DOI	10.2210/pdb7leo/pdb
Descriptor	Protein kinase C delta type, ZINC ION, (4S,7R)-7-(heptanoyloxy)-4-hydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphahexadecan-1-aminium 4-oxide, ... (5 entities in total)
Functional Keywords	c1, lipid-binding, diacylglycerol-binding, zn2+ finger, lipid binding protein
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	2
Total formula weight	14286.31
Authors	Katti, S.S.,Krieger, I. (deposition date: 2021-01-14, release date: 2022-05-04, Last modification date: 2023-10-18)
Primary citation	Katti, S.S.,Krieger, I.V.,Ann, J.,Lee, J.,Sacchettini, J.C.,Igumenova, T.I. Structural anatomy of Protein Kinase C C1 domain interactions with diacylglycerol and other agonists. Nat Commun, 13:2695-2695, 2022 Cited by PubMed: 35577811 DOI: 10.1038/s41467-022-30389-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation