7LEN

Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose

7LEN の概要

• エントリーDOI: 10.2210/pdb7len/pdb
• 分子名称: Isoform 4 of Epidermal growth factor receptor, Proepiregulin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: receptor, epiregulin, glioblastoma, cancer, mutation, extracellular, asymmetric, dimer, erbb1, egfr, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127324.11

構造登録者

Hu, C.,Leche II, C.A.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A. (登録日: 2021-01-14, 公開日: 2021-11-17, 最終更新日: 2023-10-18)

• 主引用文献: Hu, C.,Leche 2nd, C.A.,Kiyatkin, A.,Yu, Z.,Stayrook, S.E.,Ferguson, K.M.,Lemmon, M.A.; Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.; Nature, 602:518-522, 2022; PubMed: 35140400; DOI: 10.1038/s41586-021-04393-3

実験手法

X-RAY DIFFRACTION (2.9 Å)