7LCU
X-ray structure of Furin bound to BOS-318, a small molecule inhibitor
Summary for 7LCU
Entry DOI | 10.2210/pdb7lcu/pdb |
Descriptor | Furin, CALCIUM ION, (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, ... (5 entities in total) |
Functional Keywords | inhibitor protease, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 54367.55 |
Authors | Campobasso, N.,Reid, R. (deposition date: 2021-01-11, release date: 2022-01-12, Last modification date: 2023-10-18) |
Primary citation | Douglas, L.E.J.,Reihill, J.A.,Ho, M.W.Y.,Axten, J.M.,Campobasso, N.,Schneck, J.L.,Rendina, A.R.,Wilcoxen, K.M.,Martin, S.L. A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chem Biol, 29:947-957.e8, 2022 Cited by PubMed: 35202587DOI: 10.1016/j.chembiol.2022.02.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
Download full validation report