7LCU

X-ray structure of Furin bound to BOS-318, a small molecule inhibitor

7LCU の概要

• エントリーDOI: 10.2210/pdb7lcu/pdb
• 分子名称: Furin, CALCIUM ION, (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, ... (5 entities in total)
• 機能のキーワード: inhibitor protease, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 54367.55

構造登録者

Campobasso, N.,Reid, R. (登録日: 2021-01-11, 公開日: 2022-01-12, 最終更新日: 2023-10-18)

• 主引用文献: Douglas, L.E.J.,Reihill, J.A.,Ho, M.W.Y.,Axten, J.M.,Campobasso, N.,Schneck, J.L.,Rendina, A.R.,Wilcoxen, K.M.,Martin, S.L.; A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.; Cell Chem Biol, 29:947-957.e8, 2022; PubMed: 35202587; DOI: 10.1016/j.chembiol.2022.02.001

実験手法

X-RAY DIFFRACTION (1.24 Å)