7LCQ

N-terminal finger stabilizes feline drug GC376 in coronavirus 3CL protease

7LCQ の概要

• エントリーDOI: 10.2210/pdb7lcq/pdb
• 分子名称: 3C-like proteinase, 1,2-ETHANEDIOL, N~2~-[(benzyloxy)carbonyl]-N-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-leucinamide, ... (4 entities in total)
• 機能のキーワード: covid-19, sars-cov-1, 3clpro, coronavirus, main protease, kinetics, sars, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus (SARS-CoV)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34406.26

構造登録者

Khan, M.B.,Arutyunova, E.,Young, H.S.,Lemieux, M.J. (登録日: 2021-01-11, 公開日: 2021-05-12, 最終更新日: 2023-10-18)

• 主引用文献: Arutyunova, E.,Khan, M.B.,Fischer, C.,Lu, J.,Lamer, T.,Vuong, W.,van Belkum, M.J.,McKay, R.T.,Tyrrell, D.L.,Vederas, J.C.,Young, H.S.,Lemieux, M.J.; N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 M pro Dimer.; J.Mol.Biol., 433:167003-167003, 2021; PubMed: 33895266; DOI: 10.1016/j.jmb.2021.167003

実験手法

X-RAY DIFFRACTION (2.15 Å)