7LC4

Crystal structure of Pseudomonas aeruginosa PBP3 in complex with gamma-lactam YU253911

7LC4 の概要

• エントリーDOI: 10.2210/pdb7lc4/pdb
• 分子名称: Peptidoglycan D,D-transpeptidase FtsI, 1-[(2S)-2-{[(2Z)-2-(2-amino-5-chloro-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6-dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid (3 entities in total)
• 機能のキーワード: pbp3, gamma-lactam, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 59052.52

構造登録者

van den Akker, F.,Kumar, V. (登録日: 2021-01-09, 公開日: 2021-04-28, 最終更新日: 2023-10-18)

• 主引用文献: Goldberg, J.A.,Kumar, V.,Spencer, E.J.,Hoyer, D.,Marshall, S.H.,Hujer, A.M.,Hujer, K.M.,Bethel, C.R.,Papp-Wallace, K.M.,Perez, F.,Jacobs, M.R.,van Duin, D.,Kreiswirth, B.N.,van den Akker, F.,Plummer, M.S.,Bonomo, R.A.; A gamma-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.; Eur.J.Med.Chem., 220:113436-113436, 2021; PubMed: 33933754; DOI: 10.1016/j.ejmech.2021.113436

実験手法

X-RAY DIFFRACTION (2 Å)