7LC2

Crystal Structure of KRAS4b-Q61R (GMPPNP-bound) in complex with the RAS-binding domain (RBD) of SIN1

Summary for 7LC2

Entry DOI	10.2210/pdb7lc2/pdb
Descriptor	GTPase KRas, Target of rapamycin complex 2 subunit MAPKAP1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (5 entities in total)
Functional Keywords	kras, ras, k-ras, small gtpase, oncoprotein, gmppnp, gppnhp mapkap1, mtorc2, sin1, rbd, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	59832.14
Authors	Dharmaiah, S.,Simanshu, D.K. (deposition date: 2021-01-09, release date: 2021-07-28, Last modification date: 2023-11-15)
Primary citation	Castel, P.,Dharmaiah, S.,Sale, M.J.,Messing, S.,Rizzuto, G.,Cuevas-Navarro, A.,Cheng, A.,Trnka, M.J.,Urisman, A.,Esposito, D.,Simanshu, D.K.,McCormick, F. RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34380736 DOI: 10.1073/pnas.2103261118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation