7LBF

CryoEM structure of the HCMV Trimer gHgLgO in complex with human Platelet-derived growth factor receptor alpha and neutralizing fabs 13H11 and MSL-109

7LBF の概要

• エントリーDOI: 10.2210/pdb7lbf/pdb
• EMDBエントリー: 23253
• 分子名称: Envelope glycoprotein H, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• 機能のキーワード: virus, receptor, complex, neutralizing antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human cytomegalovirus (strain Merlin) (HHV-5); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 349960.31

構造登録者

Kschonsak, M.,Rouge, L.,Arthur, C.P.,Hoangdung, H.,Patel, N.,Kim, I.,Johnson, M.,Kraft, E.,Rohou, A.L.,Gill, A.,Martinez-Martin, N.,Payandeh, J.,Ciferri, C. (登録日: 2021-01-07, 公開日: 2021-03-10, 最終更新日: 2021-03-17)

• 主引用文献: Kschonsak, M.,Rouge, L.,Arthur, C.P.,Hoangdung, H.,Patel, N.,Kim, I.,Johnson, M.C.,Kraft, E.,Rohou, A.L.,Gill, A.,Martinez-Martin, N.,Payandeh, J.,Ciferri, C.; Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry.; Cell, 184:1232-, 2021; PubMed: 33626330; DOI: 10.1016/j.cell.2021.01.036

実験手法

ELECTRON MICROSCOPY (2.8 Å)