7LAW

crystal structure of GITR complex with GITR-L

Summary for 7LAW

Entry DOI	10.2210/pdb7law/pdb
Descriptor	Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	gitr-ligand, receptor, complex, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	61649.56
Authors	Longenecker, K.L.,Rogers, B.,Bigelow, L.,Judge, R.A.,Alvarez, H. (deposition date: 2021-01-07, release date: 2022-03-09, Last modification date: 2023-10-18)
Primary citation	Chan, S.,Belmar, N.,Ho, S.,Rogers, B.,Stickler, M.,Graham, M.,Lee, E.,Tran, N.,Zhang, D.,Gupta, P.,Sho, M.,MacDonough, T.,Woolley, A.,Kim, H.,Zhang, H.,Liu, W.,Zheng, P.,Dezso, Z.,Halliwill, K.,Ceccarelli, M.,Rhodes, S.,Thakur, A.,Forsyth, C.M.,Xiong, M.,Tan, S.S.,Iyer, R.,Lake, M.,Digiammarino, E.,Zhou, L.,Bigelow, L.,Longenecker, K.,Judge, R.A.,Liu, C.,Trumble, M.,Remis, J.P.,Fox, M.,Cairns, B.,Akamatsu, Y.,Hollenbaugh, D.,Harding, F.,Alvarez, H.M. An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy. Nat Cancer, 3:337-354, 2022 Cited by PubMed: 35256819 DOI: 10.1038/s43018-022-00334-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.752 Å)

Structure validation