7LAW

crystal structure of GITR complex with GITR-L

7LAW の概要

• エントリーDOI: 10.2210/pdb7law/pdb
• 分子名称: Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: gitr-ligand, receptor, complex, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 61649.56

構造登録者

Longenecker, K.L.,Rogers, B.,Bigelow, L.,Judge, R.A.,Alvarez, H. (登録日: 2021-01-07, 公開日: 2022-03-09, 最終更新日: 2023-10-18)

• 主引用文献: Chan, S.,Belmar, N.,Ho, S.,Rogers, B.,Stickler, M.,Graham, M.,Lee, E.,Tran, N.,Zhang, D.,Gupta, P.,Sho, M.,MacDonough, T.,Woolley, A.,Kim, H.,Zhang, H.,Liu, W.,Zheng, P.,Dezso, Z.,Halliwill, K.,Ceccarelli, M.,Rhodes, S.,Thakur, A.,Forsyth, C.M.,Xiong, M.,Tan, S.S.,Iyer, R.,Lake, M.,Digiammarino, E.,Zhou, L.,Bigelow, L.,Longenecker, K.,Judge, R.A.,Liu, C.,Trumble, M.,Remis, J.P.,Fox, M.,Cairns, B.,Akamatsu, Y.,Hollenbaugh, D.,Harding, F.,Alvarez, H.M.; An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy.; Nat Cancer, 3:337-354, 2022; PubMed: 35256819; DOI: 10.1038/s43018-022-00334-9

実験手法

X-RAY DIFFRACTION (2.752 Å)