7LAL

CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-18 AKA 7-(3-(2,3-DIHYDRO-1H-INDEN-1-YLAMINO)-1-PHENYLPROPYL)-1H-[1,2,3]TRIAZOLO[4,5-B]PYRIDIN-5-AMINE

7LAL の概要

• エントリーDOI: 10.2210/pdb7lal/pdb
• 分子名称: Myeloperoxidase light chain, 7-[(1R)-3-{[(1R)-2,3-dihydro-1H-inden-1-yl]amino}-1-phenylpropyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, Isoform H14 of Myeloperoxidase, ... (11 entities in total)
• 機能のキーワード: myeloperoxidase, oxidoreductase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 135392.29

構造登録者

Khan, J.A. (登録日: 2021-01-06, 公開日: 2021-04-21, 最終更新日: 2023-10-18)

• 主引用文献: Hu, C.H.,Neissel Valente, M.W.,Halpern, O.S.,Jusuf, S.,Khan, J.A.,Locke, G.A.,Duke, G.J.,Liu, X.,Duclos, F.J.,Wexler, R.R.,Kick, E.K.,Smallheer, J.M.; Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO).; Bioorg.Med.Chem.Lett., 42:128010-128010, 2021; PubMed: 33811992; DOI: 10.1016/j.bmcl.2021.128010

実験手法

X-RAY DIFFRACTION (2.75 Å)