7L99

Crystal structure of BRDT bromodomain 2 in complex with CDD-1302

7L99 の概要

• エントリーDOI: 10.2210/pdb7l99/pdb
• 分子名称: Bromodomain testis-specific protein, N-[3-(acetylamino)-4-methylphenyl]-3-(4-amino-2-methylphenyl)-1-methyl-1H-indazole-5-carboxamide, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500), ... (4 entities in total)
• 機能のキーワード: inhibitor complex, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 66266.97

構造登録者

Sharma, R.,Yu, Z.,Ku, A.F.,Anglin, J.L.,Ucisik, M.N.,Faver, J.C.,Sankaran, B.,Kim, C.,Matzuk, M.M. (登録日: 2021-01-03, 公開日: 2021-06-30, 最終更新日: 2023-10-18)

• 主引用文献: Yu, Z.,Ku, A.F.,Anglin, J.L.,Sharma, R.,Ucisik, M.N.,Faver, J.C.,Li, F.,Nyshadham, P.,Simmons, N.,Sharma, K.L.,Nagarajan, S.,Riehle, K.,Kaur, G.,Sankaran, B.,Storl-Desmond, M.,Palmer, S.S.,Young, D.W.,Kim, C.,Matzuk, M.M.; Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33637650; DOI: 10.1073/pnas.2021102118

実験手法

X-RAY DIFFRACTION (1.9 Å)