7L8P
Integrin alphaIIbbeta3 in complex with sibrafiban
Summary for 7L8P
Entry DOI | 10.2210/pdb7l8p/pdb |
Descriptor | Isoform 3 of Integrin alpha-IIb, CALCIUM ION, MAGNESIUM ION, ... (15 entities in total) |
Functional Keywords | cell adhesion, platelet aggregation, membrane protein-immune system complex, integrin inhibitor, rgd mimetics |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 302474.58 |
Authors | Lin, F.-Y.,Springer, T.A. (deposition date: 2020-12-31, release date: 2022-06-15, Last modification date: 2023-10-25) |
Primary citation | Lin, F.Y.,Li, J.,Xie, Y.,Zhu, J.,Huong Nguyen, T.T.,Zhang, Y.,Zhu, J.,Springer, T.A. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185:3533-3550.e27, 2022 Cited by PubMed: 36113427DOI: 10.1016/j.cell.2022.08.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3499537016 Å) |
Structure validation
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