7L7E
Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061
Summary for 7L7E
Entry DOI | 10.2210/pdb7l7e/pdb |
Descriptor | heavy chain of human monoclonal antibody AZD8895, light chain of human monoclonal antibody Fab AZD8895, heavy chain of human monoclonal antibody Fab AZD1061, ... (8 entities in total) |
Functional Keywords | sars-cov-2, spike protein, receptor binding domain, human monoclonal antibody, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 20 |
Total formula weight | 485421.52 |
Authors | Dong, J.,Crowe, J.E. (deposition date: 2020-12-28, release date: 2021-09-01, Last modification date: 2023-10-18) |
Primary citation | Dong, J.,Zost, S.J.,Greaney, A.J.,Starr, T.N.,Dingens, A.S.,Chen, E.C.,Chen, R.E.,Case, J.B.,Sutton, R.E.,Gilchuk, P.,Rodriguez, J.,Armstrong, E.,Gainza, C.,Nargi, R.S.,Binshtein, E.,Xie, X.,Zhang, X.,Shi, P.Y.,Logue, J.,Weston, S.,McGrath, M.E.,Frieman, M.B.,Brady, T.,Tuffy, K.M.,Bright, H.,Loo, Y.M.,McTamney, P.M.,Esser, M.T.,Carnahan, R.H.,Diamond, M.S.,Bloom, J.D.,Crowe Jr., J.E. Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail. Nat Microbiol, 6:1233-1244, 2021 Cited by PubMed: 34548634DOI: 10.1038/s41564-021-00972-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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