7L7D

Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibody AZD8895

7L7D の概要

• エントリーDOI: 10.2210/pdb7l7d/pdb
• 分子名称: heavy chain of human monoclonal antibody Fab AZD8895, light chain of human monoclonal antibody Fab AZD8895, Spike protein S1, ... (6 entities in total)
• 機能のキーワード: sars-cov-2, spike protein, receptor binding domain, human monoclonal antibody, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 72747.45

構造登録者

Dong, J.,Crowe, J.E. (登録日: 2020-12-28, 公開日: 2021-09-01, 最終更新日: 2023-10-18)

• 主引用文献: Dong, J.,Zost, S.J.,Greaney, A.J.,Starr, T.N.,Dingens, A.S.,Chen, E.C.,Chen, R.E.,Case, J.B.,Sutton, R.E.,Gilchuk, P.,Rodriguez, J.,Armstrong, E.,Gainza, C.,Nargi, R.S.,Binshtein, E.,Xie, X.,Zhang, X.,Shi, P.Y.,Logue, J.,Weston, S.,McGrath, M.E.,Frieman, M.B.,Brady, T.,Tuffy, K.M.,Bright, H.,Loo, Y.M.,McTamney, P.M.,Esser, M.T.,Carnahan, R.H.,Diamond, M.S.,Bloom, J.D.,Crowe Jr., J.E.; Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.; Nat Microbiol, 6:1233-1244, 2021; PubMed: 34548634; DOI: 10.1038/s41564-021-00972-2

実験手法

X-RAY DIFFRACTION (2.5 Å)