7L35
Human DNA Ligase 1 - R771W nicked DNA complex
Summary for 7L35
Entry DOI | 10.2210/pdb7l35/pdb |
Descriptor | DNA ligase 1, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*GP*AP*C)-3'), ... (9 entities in total) |
Functional Keywords | dna ligase, ligase, ligase-dna complex, ligase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 83645.91 |
Authors | Tumbale, P.P.,Williams, R.S.,Schellenberg, M.S. (deposition date: 2020-12-17, release date: 2021-01-13, Last modification date: 2023-10-18) |
Primary citation | Jurkiw, T.J.,Tumbale, P.P.,Schellenberg, M.J.,Cunningham-Rundles, C.,Williams, R.S.,O'Brien, P.J. LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency. Nucleic Acids Res., 49:1619-1630, 2021 Cited by PubMed: 33444456DOI: 10.1093/nar/gkaa1297 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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