7L26

HPK1 IN COMPLEX WITH COMPOUND 38

7L26 の概要

• エントリーDOI: 10.2210/pdb7l26/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase kinase 1, 6-(2-fluoro-6-methylphenyl)-1-[4-(4-methylpiperazin-1-yl)phenyl]-1H-indazole-5-carbonitrile (3 entities in total)
• 機能のキーワード: hpk1 hematopoietic progenitor kinase, inhibitor complex, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130584.49

構造登録者

Lesburg, C.A. (登録日: 2020-12-16, 公開日: 2021-03-17, 最終更新日: 2024-04-03)

• 主引用文献: Yu, E.C.,Methot, J.L.,Fradera, X.,Lesburg, C.A.,Lacey, B.M.,Siliphaivanh, P.,Liu, P.,Smith, D.M.,Xu, Z.,Piesvaux, J.A.,Kawamura, S.,Xu, H.,Miller, J.R.,Bittinger, M.,Pasternak, A.; Identification of Potent Reverse Indazole Inhibitors for HPK1.; Acs Med.Chem.Lett., 12:459-466, 2021; PubMed: 33738073; DOI: 10.1021/acsmedchemlett.0c00672

実験手法

X-RAY DIFFRACTION (2.3 Å)