7L0D

SARS-CoV-2 Main Protease (Mpro) in Complex with ML188

7L0D の概要

• エントリーDOI: 10.2210/pdb7l0d/pdb
• 分子名称: 3C-like proteinase, N-[(1R)-2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide (3 entities in total)
• 機能のキーワード: sars-cov-2, covid19 protease, protease inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2, COVID-19 virus)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34259.09

構造登録者

Lockbaum, G.J.,Lee, J.M.,Reyes, A.C.,Nalivaika, E.A.,Ali, A.,Yilmaz, N.K.,Thompson, P.R.,Schiffer, C.A. (登録日: 2020-12-11, 公開日: 2021-02-10, 最終更新日: 2023-10-18)

• 主引用文献: Lockbaum, G.J.,Reyes, A.C.,Lee, J.M.,Tilvawala, R.,Nalivaika, E.A.,Ali, A.,Kurt Yilmaz, N.,Thompson, P.R.,Schiffer, C.A.; Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.; Viruses, 13:-, 2021; PubMed: 33503819; DOI: 10.3390/v13020174

実験手法

X-RAY DIFFRACTION (2.39 Å)