7KWU

Crystal Structure of HIV-1 RT in Complex with 16c (K07-15)

7KWU の概要

• エントリーDOI: 10.2210/pdb7kwu/pdb
• 分子名称: Reverse transcriptase p66, Reverse transcriptase p51, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: human immunodeficiency virus 1, non nucleotide-reverse transcriptase inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115530.42

構造登録者

Ruiz, F.X.,Arnold, E. (登録日: 2020-12-02, 公開日: 2021-03-31, 最終更新日: 2023-10-18)

• 主引用文献: Kang, D.,Ruiz, F.X.,Sun, Y.,Feng, D.,Jing, L.,Wang, Z.,Zhang, T.,Gao, S.,Sun, L.,De Clercq, E.,Pannecouque, C.,Arnold, E.,Zhan, P.,Liu, X.; 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies.; J.Med.Chem., 64:4239-4256, 2021; PubMed: 33734714; DOI: 10.1021/acs.jmedchem.1c00268

実験手法

X-RAY DIFFRACTION (2.02 Å)