7KVZ
Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-2
Summary for 7KVZ
Entry DOI | 10.2210/pdb7kvz/pdb |
Descriptor | Stimulator of interferon genes protein, (2R,5R,7R,8R,10S,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,10,16-trihydroxy-14-[(pyrimidin-4-yl)oxy]decahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione (3 entities in total) |
Functional Keywords | immunotherapy, stimulator of interferon genes, cyclic dinucleotide, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27829.02 |
Authors | Skene, R.J. (deposition date: 2020-11-29, release date: 2022-02-09, Last modification date: 2023-10-18) |
Primary citation | Vyskocil, S.,Cardin, D.,Ciavarri, J.,Conlon, J.,Cullis, C.,England, D.,Gershman, R.,Gigstad, K.,Gipson, K.,Gould, A.,Greenspan, P.,Griffin, R.,Gulavita, N.,Harrison, S.,Hu, Z.,Hu, Y.,Hata, A.,Huang, J.,Huang, S.C.,Janowick, D.,Jones, M.,Kolev, V.,Langston, S.P.,Lee, H.M.,Li, G.,Lok, D.,Ma, L.,Mai, D.,Malley, J.,Matsuda, A.,Mizutani, H.,Mizutani, M.,Molchanova, N.,Nunes, E.,Pusalkar, S.,Renou, C.,Rowland, S.,Sato, Y.,Shaw, M.,Shen, L.,Shi, Z.,Skene, R.,Soucy, F.,Stroud, S.,Xu, H.,Xu, T.,Abu-Yousif, A.O.,Zhang, J. Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route. J.Med.Chem., 64:6902-6923, 2021 Cited by PubMed: 34000802DOI: 10.1021/acs.jmedchem.1c00374 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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