7KQU

A 1.58-A resolution crystal structure of ferric-hydroperoxo intermediate of L-tyrosine hydroxylase in complex with 3-fluoro-L-tyrosine

7KQU の概要

• エントリーDOI: 10.2210/pdb7kqu/pdb
• 分子名称: Heme-dependent L-tyrosine hydroxylase, PROTOPORPHYRIN IX CONTAINING FE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (7 entities in total)
• 機能のキーワード: heme-binding enzyme, l-tyrosine hydroxylase, oxidoreductase
• 由来する生物種: Streptomyces sclerotialus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71276.92

構造登録者

Wang, Y.,Davis, I.,Liu, A. (登録日: 2020-11-17, 公開日: 2021-03-31, 最終更新日: 2023-10-18)

• 主引用文献: Wang, Y.,Davis, I.,Shin, I.,Xu, H.,Liu, A.; Molecular Rationale for Partitioning between C-H and C-F Bond Activation in Heme-Dependent Tyrosine Hydroxylase.; J.Am.Chem.Soc., 143:4680-4693, 2021; PubMed: 33734681; DOI: 10.1021/jacs.1c00175

実験手法

X-RAY DIFFRACTION (1.579 Å)