7KP9

asymmetric hTNF-alpha

7KP9 の概要

• エントリーDOI: 10.2210/pdb7kp9/pdb
• 分子名称: Tumor necrosis factor, 1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole (3 entities in total)
• 機能のキーワード: tumour necrosis factor alpha, tnf, asymmetric, protein-protein inhibitor, cytokine
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 52822.70

構造登録者

Arakaki, T.L.,Abendroth, J.,Fairman, J.W.,Foley, A.,Ceska, T. (登録日: 2020-11-10, 公開日: 2021-01-13, 最終更新日: 2024-04-03)

• 主引用文献: McMillan, D.,Martinez-Fleites, C.,Porter, J.,Fox 3rd, D.,Davis, R.,Mori, P.,Ceska, T.,Carrington, B.,Lawson, A.,Bourne, T.,O'Connell, J.; Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF.; Nat Commun, 12:582-582, 2021; PubMed: 33495441; DOI: 10.1038/s41467-020-20828-3

実験手法

X-RAY DIFFRACTION (2.15 Å)