7KO0

Crystal structure of the second bromodomain (BD2) of human BRD4 bound to SG3-179

Summary for 7KO0

Entry DOI	10.2210/pdb7ko0/pdb
Descriptor	Bromodomain-containing protein 4, 4-[[4-[[3-(~{tert}-butylsulfonylamino)-4-chloranyl-phenyl]amino]-5-methyl-pyrimidin-2-yl]amino]-2-fluoranyl-~{N}-(1-methylpiperidin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	bet, erk5, plk1, dual brd-kinase inhibitor, gene regulation
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13773.42
Authors	Karim, M.R.,Zhu, J.Y.,Schonbrunn, E. (deposition date: 2020-11-06, release date: 2021-10-20, Last modification date: 2023-10-18)
Primary citation	Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E. Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64:15772-15786, 2021 Cited by PubMed: 34710325 DOI: 10.1021/acs.jmedchem.1c01096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation