7KN5

Crystal structure of SARS-CoV-2 receptor binding domain complexed with nanobodies VHH E and U

7KN5 の概要

• エントリーDOI: 10.2210/pdb7kn5/pdb
• 分子名称: Spike protein S1, VHH E, VHH U, ... (7 entities in total)
• 機能のキーワード: sars-cov-2, nanobody, spike, coronavirus, covid-19, immune system, nanobody-antigen complex, single-domain antibody, viral protein, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 108765.65

構造登録者

Liu, H.,Yuan, M.,Zhu, X.,Wu, N.C.,Wilson, I.A. (登録日: 2020-11-04, 公開日: 2021-01-20, 最終更新日: 2023-10-18)

• 主引用文献: Koenig, P.A.,Das, H.,Liu, H.,Kummerer, B.M.,Gohr, F.N.,Jenster, L.M.,Schiffelers, L.D.J.,Tesfamariam, Y.M.,Uchima, M.,Wuerth, J.D.,Gatterdam, K.,Ruetalo, N.,Christensen, M.H.,Fandrey, C.I.,Normann, S.,Todtmann, J.M.P.,Pritzl, S.,Hanke, L.,Boos, J.,Yuan, M.,Zhu, X.,Schmid-Burgk, J.L.,Kato, H.,Schindler, M.,Wilson, I.A.,Geyer, M.,Ludwig, K.U.,Hallberg, B.M.,Wu, N.C.,Schmidt, F.I.; Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.; Science, 371:-, 2021; PubMed: 33436526; DOI: 10.1126/science.abe6230

実験手法

X-RAY DIFFRACTION (1.87 Å)