7KKH

P1A4 Fab in complex with ARS1620

Summary for 7KKH

• Entry DOI: 10.2210/pdb7kkh/pdb
• Descriptor: P1A4 Fab Light Chain, P1A4 Fab Heavy Chain, SODIUM ION, ... (5 entities in total)
• Functional Keywords: fab, antibody, antitumor protein, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 46682.18

Authors

Basu, K.,Rohweder, P.J.,Zhang, Z.,Bohn, M.-F.,Shokat, K.,Craik, C.S. (deposition date: 2020-10-27, release date: 2022-04-27, Last modification date: 2023-10-18)

• Primary citation: Zhang, Z.,Rohweder, P.J.,Ongpipattanakul, C.,Basu, K.,Bohn, M.F.,Dugan, E.J.,Steri, V.,Hann, B.,Shokat, K.M.,Craik, C.S.; A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy.; Cancer Cell, 40:1060-1069.e7, 2022; PubMed: 36099883; DOI: 10.1016/j.ccell.2022.07.005

Experimental method

X-RAY DIFFRACTION (2 Å)