7KKH
P1A4 Fab in complex with ARS1620
Summary for 7KKH
Entry DOI | 10.2210/pdb7kkh/pdb |
Descriptor | P1A4 Fab Light Chain, P1A4 Fab Heavy Chain, SODIUM ION, ... (5 entities in total) |
Functional Keywords | fab, antibody, antitumor protein, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 46682.18 |
Authors | Basu, K.,Rohweder, P.J.,Zhang, Z.,Bohn, M.-F.,Shokat, K.,Craik, C.S. (deposition date: 2020-10-27, release date: 2022-04-27, Last modification date: 2023-10-18) |
Primary citation | Zhang, Z.,Rohweder, P.J.,Ongpipattanakul, C.,Basu, K.,Bohn, M.F.,Dugan, E.J.,Steri, V.,Hann, B.,Shokat, K.M.,Craik, C.S. A covalent inhibitor of K-Ras(G12C) induces MHC class I presentation of haptenated peptide neoepitopes targetable by immunotherapy. Cancer Cell, 40:1060-1069.e7, 2022 Cited by PubMed: 36099883DOI: 10.1016/j.ccell.2022.07.005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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