7KIV

Crystal structure of Pseudomonas aeruginosa PBP3 in complex with avibactam

7KIV の概要

• エントリーDOI: 10.2210/pdb7kiv/pdb
• 分子名称: Peptidoglycan D,D-transpeptidase FtsI, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total)
• 機能のキーワード: inhibitor, cell wall, antibiotic resistance, hydrolase, hydrolase-inhibitor-antibiotic complex, hydrolase/inhibitor/antibiotic
• 由来する生物種: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63200.34

構造登録者

van den Akker, F. (登録日: 2020-10-24, 公開日: 2021-01-13, 最終更新日: 2023-10-18)

• 主引用文献: Rajavel, M.,Kumar, V.,Nguyen, H.,Wyatt, J.,Marshall, S.H.,Papp-Wallace, K.M.,Deshpande, P.,Bhavsar, S.,Yeole, R.,Bhagwat, S.,Patel, M.,Bonomo, R.A.,van den Akker, F.; Structural Characterization of Diazabicyclooctane beta-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa.; Mbio, 12:-, 2021; PubMed: 33593978; DOI: 10.1128/mBio.03058-20

実験手法

X-RAY DIFFRACTION (2.389 Å)