7KHZ

Crystal structure of OXA-163 K73A in complex with imipenem

Summary for 7KHZ

• Entry DOI: 10.2210/pdb7khz/pdb
• Related: 7KHQ
• Descriptor: Beta-lactamase, (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: beta-lactamase, carbapenemase, beta-lactamase inhibitor, complex, oxacillinase, hydrolase, hydrolase-hydrolase inhibitor complex
• Biological source: Enterobacter cloacae
• Total number of polymer chains: 1
• Total formula weight: 28127.60

Authors

Palzkill, T.,Hu, L.,Sankaran, B.,Prasad, B.V.V. (deposition date: 2020-10-22, release date: 2021-02-10, Last modification date: 2023-10-18)

• Primary citation: Stojanoski, V.,Hu, L.,Sankaran, B.,Wang, F.,Tao, P.,Prasad, B.V.V.,Palzkill, T.; Mechanistic Basis of OXA-48-like beta-Lactamases' Hydrolysis of Carbapenems.; Acs Infect Dis., 7:445-460, 2021; PubMed: 33492952; DOI: 10.1021/acsinfecdis.0c00798

Experimental method

X-RAY DIFFRACTION (2.04 Å)