7KGY

Beta-glucuronidase from Faecalibacterium prausnitzii bound to the inhibitor UNC10201652-glucuronide

7KGY の概要

• エントリーDOI: 10.2210/pdb7kgy/pdb
• 分子名称: Beta-glucuronidase, 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: beta-glucuronidase, carbohydrate, glucuronic acid, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Faecalibacterium prausnitzii
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 279049.28

構造登録者

Simpson, J.B.,Redinbo, M.R. (登録日: 2020-10-19, 公開日: 2021-11-10, 最終更新日: 2023-10-18)

• 主引用文献: Zhang, J.,Walker, M.E.,Sanidad, K.Z.,Zhang, H.,Liang, Y.,Zhao, E.,Chacon-Vargas, K.,Yeliseyev, V.,Parsonnet, J.,Haggerty, T.D.,Wang, G.,Simpson, J.B.,Jariwala, P.B.,Beaty, V.V.,Yang, J.,Yang, H.,Panigrahy, A.,Minter, L.M.,Kim, D.,Gibbons, J.G.,Liu, L.,Li, Z.,Xiao, H.,Borlandelli, V.,Overkleeft, H.S.,Cloer, E.W.,Major, M.B.,Goldfarb, D.,Cai, Z.,Redinbo, M.R.,Zhang, G.; Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.; Nat Commun, 13:136-136, 2022; PubMed: 35013263; DOI: 10.1038/s41467-021-27762-y

実験手法

X-RAY DIFFRACTION (2.2 Å)