7KDP

HCMV prefusion gB in complex with fusion inhibitor WAY-174865

7KDP の概要

• エントリーDOI: 10.2210/pdb7kdp/pdb
• EMDBエントリー: 22828
• 分子名称: Envelope glycoprotein B, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{4-[({(1S)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}carbamothioyl)amino]phenyl}-1,3-thiazole-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: fusogen, prefusion, hcmv, gb, antibody, viral protein, fusion inhibitor, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human cytomegalovirus (strain Towne) (HHV-5)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 314434.88

構造登録者

Liu, Y.,Heim, P.K.,Che, Y.,Chi, X.,Qiu, X.,Han, S.,Dormitzer, P.R.,Yang, X. (登録日: 2020-10-09, 公開日: 2021-03-17)

• 主引用文献: Liu, Y.,Heim, K.P.,Che, Y.,Chi, X.,Qiu, X.,Han, S.,Dormitzer, P.R.,Yang, X.; Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion.; Sci Adv, 7:-, 2021; PubMed: 33674318; DOI: 10.1126/sciadv.abf3178

実験手法

ELECTRON MICROSCOPY (3.6 Å)