7KCW
Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with nafcillin
Summary for 7KCW
Entry DOI | 10.2210/pdb7kcw/pdb |
Descriptor | Penicillin-binding protein 4, (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL, ... (5 entities in total) |
Functional Keywords | acyl-enzyme intermediate, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Staphylococcus aureus (strain COL) |
Total number of polymer chains | 1 |
Total formula weight | 41720.40 |
Authors | Alexander, J.A.,Strynadka, N.C. (deposition date: 2020-10-07, release date: 2021-06-30, Last modification date: 2023-10-18) |
Primary citation | Satishkumar, N.,Alexander, J.A.N.,Poon, R.,Buggeln, E.,Argudin, M.A.,Strynadka, N.C.J.,Chatterjee, S.S. PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus. J.Antimicrob.Chemother., 76:2268-2272, 2021 Cited by PubMed: 34151961DOI: 10.1093/jac/dkab201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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