7KCW

Crystal structure of S. aureus penicillin-binding protein 4 (PBP4) mutant (R200L) in complex with nafcillin

7KCW の概要

• エントリーDOI: 10.2210/pdb7kcw/pdb
• 分子名称: Penicillin-binding protein 4, (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: acyl-enzyme intermediate, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Staphylococcus aureus (strain COL)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41720.40

構造登録者

Alexander, J.A.,Strynadka, N.C. (登録日: 2020-10-07, 公開日: 2021-06-30, 最終更新日: 2024-11-20)

主引用文献

Satishkumar, N.,Alexander, J.A.N.,Poon, R.,Buggeln, E.,Argudin, M.A.,Strynadka, N.C.J.,Chatterjee, S.S.
PBP4-mediated beta-lactam resistance among clinical strains of Staphylococcus aureus.
J.Antimicrob.Chemother., 76:2268-2272, 2021

PubMed Abstract: PBP4, a low-molecular-weight PBP in Staphylococcus aureus, is not considered to be a classical mediator of β-lactam resistance. Previous studies carried out by our group with laboratory strains of S. aureus demonstrated the ability of PBP4 to produce β-lactam resistance through mutations associated with the pbp4 promoter and/or gene. Recent studies of β-lactam-resistant clinical isolates of S. aureus have reported similar mutations associated with pbp4.

PubMed: 34151961
DOI: 10.1093/jac/dkab201

実験手法

X-RAY DIFFRACTION (1.73 Å)