7KCC
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor AG-270
Summary for 7KCC
Entry DOI | 10.2210/pdb7kcc/pdb |
Related | 7KCE 7KCF 7KDA 7KDB |
Descriptor | S-adenosylmethionine synthase isoform type-2, CHLORIDE ION, 1,2-ETHANEDIOL, ... (6 entities in total) |
Functional Keywords | methionine adenosyltransferase, sam, allosteric inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 45014.89 |
Authors | Padyana, A.,Jin, L. (deposition date: 2020-10-05, release date: 2021-04-21, Last modification date: 2023-10-18) |
Primary citation | Konteatis, Z.,Travins, J.,Gross, S.,Marjon, K.,Barnett, A.,Mandley, E.,Nicolay, B.,Nagaraja, R.,Chen, Y.,Sun, Y.,Liu, Z.,Yu, J.,Ye, Z.,Jiang, F.,Wei, W.,Fang, C.,Gao, Y.,Kalev, P.,Hyer, M.L.,DeLaBarre, B.,Jin, L.,Padyana, A.K.,Dang, L.,Murtie, J.,Biller, S.A.,Sui, Z.,Marks, K.M. Discovery of AG-270, a First-in-Class Oral MAT2A Inhibitor for the Treatment of Tumors with Homozygous MTAP Deletion. J.Med.Chem., 64:4430-4449, 2021 Cited by PubMed: 33829783DOI: 10.1021/acs.jmedchem.0c01895 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.32 Å) |
Structure validation
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