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7KC5

X-ray structure of Lfa-1 I domain in complex with BMS-68852 collected at 273 K

Summary for 7KC5
Entry DOI10.2210/pdb7kc5/pdb
Related7KC3
DescriptorIntegrin alpha-L, MAGNESIUM ION, 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]pyridine-3-carboxylic acid, ... (4 entities in total)
Functional Keywordsintegrin, adhesion, cell adhesion
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight42993.29
Authors
Woldeyes, R.A.,Hallenbeck, K.K.,Pfaff, S.J.,Lee, G.,Cortez, S.V.,Kelly, M.J.,Akassoglou, K.,Arkin, M.R.,Fraser, J.S. (deposition date: 2020-10-05, release date: 2021-10-06, Last modification date: 2023-10-18)
Primary citationWoldeyes, R.A.,Hallenbeck, K.K.,Pfaff, S.J.,Lee, G.,Cortez, S.V.,Kelly, M.J.,Akassoglou, K.,Arkin, M.R.,Fraser, J.S.
Divergent conformational dynamics controls allosteric ligand accessibility across evolutionarily related I-domain-containing integrins
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.86 Å)
Structure validation

221051

數據於2024-06-12公開中

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