7KB8

Co-crystal structure of alpha glucosidase with compound 8

7KB8 の概要

• エントリーDOI: 10.2210/pdb7kb8/pdb
• 分子名称: Isoform 2 of Neutral alpha-glucosidase AB, Glucosidase 2 subunit beta, (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-[(4-{[2-nitro-4-(triazan-1-yl)phenyl]amino}butyl)amino]cyclohexane-1,2,3,4-tetrol, ... (9 entities in total)
• 機能のキーワード: alpha glucosidase ii, endoplasmic reticulum, hydrolase, inhibitor complex
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 350970.56

構造登録者

Karade, S.S.,Mariuzza, R.A. (登録日: 2020-10-01, 公開日: 2021-10-06, 最終更新日: 2023-10-18)

• 主引用文献: Karade, S.S.,Hill, M.L.,Kiappes, J.L.,Manne, R.,Aakula, B.,Zitzmann, N.,Warfield, K.L.,Treston, A.M.,Mariuzza, R.A.; N-Substituted Valiolamine Derivatives as Potent Inhibitors of Endoplasmic Reticulum alpha-Glucosidases I and II with Antiviral Activity.; J.Med.Chem., 64:18010-18024, 2021; PubMed: 34870992; DOI: 10.1021/acs.jmedchem.1c01377

実験手法

X-RAY DIFFRACTION (2.385 Å)