7K99

Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19

Summary for 7K99

• Entry DOI: 10.2210/pdb7k99/pdb
• Descriptor: UDP-3-O-acyl-N-acetylglucosamine deacetylase, GLYCEROL, (hydroxy{(1S)-1-(methylsulfanyl)-2-[5-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)-1H-benzotriazol-1-yl]ethyl}amino)methanol, ... (6 entities in total)
• Functional Keywords: lpxc, hydrolase
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 2
• Total formula weight: 69217.00

Authors

Sacco, M.,Chen, Y. (deposition date: 2020-09-28, release date: 2020-11-25, Last modification date: 2023-10-18)

• Primary citation: Furuya, T.,Shapiro, A.B.,Comita-Prevoir, J.,Kuenstner, E.J.,Zhang, J.,Ribe, S.D.,Chen, A.,Hines, D.,Moussa, S.H.,Carter, N.M.,Sylvester, M.A.,Romero, J.A.C.,Vega, C.V.,Sacco, M.D.,Chen, Y.,O'Donnell, J.P.,Durand-Reville, T.F.,Miller, A.A.,Tommasi, R.A.; N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.; Bioorg.Med.Chem., 28:115826-115826, 2020; PubMed: 33160146; DOI: 10.1016/j.bmc.2020.115826

Experimental method

X-RAY DIFFRACTION (1.9 Å)