7K99

Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19

7K99 の概要

• エントリーDOI: 10.2210/pdb7k99/pdb
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, GLYCEROL, (hydroxy{(1S)-1-(methylsulfanyl)-2-[5-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)-1H-benzotriazol-1-yl]ethyl}amino)methanol, ... (6 entities in total)
• 機能のキーワード: lpxc, hydrolase
• 由来する生物種: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69217.00

構造登録者

Sacco, M.,Chen, Y. (登録日: 2020-09-28, 公開日: 2020-11-25, 最終更新日: 2023-10-18)

• 主引用文献: Furuya, T.,Shapiro, A.B.,Comita-Prevoir, J.,Kuenstner, E.J.,Zhang, J.,Ribe, S.D.,Chen, A.,Hines, D.,Moussa, S.H.,Carter, N.M.,Sylvester, M.A.,Romero, J.A.C.,Vega, C.V.,Sacco, M.D.,Chen, Y.,O'Donnell, J.P.,Durand-Reville, T.F.,Miller, A.A.,Tommasi, R.A.; N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.; Bioorg.Med.Chem., 28:115826-115826, 2020; PubMed: 33160146; DOI: 10.1016/j.bmc.2020.115826

実験手法

X-RAY DIFFRACTION (1.9 Å)