7K93

DENV2 NS1 in complex with neutralizing 2B7 single chain Fab variable region (scFv)

Summary for 7K93

Entry DOI	10.2210/pdb7k93/pdb
Descriptor	Non-structural protein 1, 2B7 single chain fab variable region, 2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
Functional Keywords	flavivirus ns1, antibody, fab fragment, viral protein
Biological source	Dengue virus 2 More
Total number of polymer chains	8
Total formula weight	278460.14
Authors	Akey, D.L.,Smith, J.L. (deposition date: 2020-09-28, release date: 2020-12-23, Last modification date: 2023-10-18)
Primary citation	Biering, S.B.,Akey, D.L.,Wong, M.P.,Brown, W.C.,Lo, N.T.N.,Puerta-Guardo, H.,Tramontini Gomes de Sousa, F.,Wang, C.,Konwerski, J.R.,Espinosa, D.A.,Bockhaus, N.J.,Glasner, D.R.,Li, J.,Blanc, S.F.,Juan, E.Y.,Elledge, S.J.,Mina, M.J.,Beatty, P.R.,Smith, J.L.,Harris, E. Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction. Science, 371:194-200, 2021 Cited by PubMed: 33414220 DOI: 10.1126/science.abc0476 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.89 Å)

Structure validation