7K7L

Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

7K7L の概要

• エントリーDOI: 10.2210/pdb7k7l/pdb
• 分子名称: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• 機能のキーワード: serine/threonine protein kinase, signaling protein, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 118677.53

構造登録者

Spurlino, J.C.,Milligan, C. (登録日: 2020-09-23, 公開日: 2020-10-28, 最終更新日: 2024-04-03)

• 主引用文献: Xu, G.,Gaul, M.D.,Liu, Z.,DesJarlais, R.L.,Qi, J.,Wang, W.,Krosky, D.,Petrounia, I.,Milligan, C.M.,Hermans, A.,Lu, H.R.,Huang, D.Z.,Xu, J.Z.,Spurlino, J.C.; Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.; Bioorg.Med.Chem.Lett., 30:127602-127602, 2020; PubMed: 33038544; DOI: 10.1016/j.bmcl.2020.127602

実験手法

X-RAY DIFFRACTION (2.539 Å)