7K6H

Crystal structure of the first bromodomain (BD1) of human BRD4 bound to XMD8-92

7K6H の概要

• エントリーDOI: 10.2210/pdb7k6h/pdb
• 分子名称: Bromodomain-containing protein 4, 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total)
• 機能のキーワード: bet, erk5, dual brd-kinase inhibitor, gene regulation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15573.93

構造登録者

Karim, M.R.,Zhu, J.Y.,Schonbrunn, E. (登録日: 2020-09-20, 公開日: 2021-09-22, 最終更新日: 2023-10-18)

• 主引用文献: Karim, R.M.,Bikowitz, M.J.,Chan, A.,Zhu, J.Y.,Grassie, D.,Becker, A.,Berndt, N.,Gunawan, S.,Lawrence, N.J.,Schonbrunn, E.; Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors.; J.Med.Chem., 64:15772-15786, 2021; PubMed: 34710325; DOI: 10.1021/acs.jmedchem.1c01096

実験手法

X-RAY DIFFRACTION (1.5 Å)