7K69

Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001574

Summary for 7K69

• Entry DOI: 10.2210/pdb7k69/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-{2-[2-(2,4-diamino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-oxoethoxy]phenyl}piperidine-4-carboxylic acid, ... (5 entities in total)
• Functional Keywords: ssgcid, sddc, inhibitor, structural genomics, seattle structural genomics center for infectious disease, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium ulcerans (strain Agy99)
• Total number of polymer chains: 1
• Total formula weight: 20312.62

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-09-19, release date: 2021-03-17, Last modification date: 2023-10-18)

• Primary citation: Abendroth, J.,Dranow, D.M.,Santhakumar, V.,Walpole, C.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.; Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex with NADP and inhibitor SDDC-0001574; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)