7K65

Hedgehog receptor Patched (PTCH1) in complex with conformation selective nanobody TI23

Summary for 7K65

Entry DOI	10.2210/pdb7k65/pdb
EMDB information	22689
Descriptor	Protein patched homolog 1, nanobody TI23, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	membrane protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	2
Total formula weight	162633.06
Authors	Zhang, Y.,Bulkley, D.P.,Liang, J.,Manglik, A.,Cheng, Y.,Beachy, P.A. (deposition date: 2020-09-18, release date: 2021-03-17)
Primary citation	Zhang, Y.,Lu, W.J.,Bulkley, D.P.,Liang, J.,Ralko, A.,Han, S.,Roberts, K.J.,Li, A.,Cho, W.,Cheng, Y.,Manglik, A.,Beachy, P.A. Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit. Proc.Natl.Acad.Sci.USA, 117:28838-28846, 2020 Cited by PubMed: 33139559 DOI: 10.1073/pnas.2011560117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation