7K5M
CRYSTAL STRUCTURE OF HBV CAPSID Y132A MUTANT IN COMPLEX WITH N-(3-chloro-4-fluorophenyl)-3-phenyl-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide AT 2.65A RESOLUTION
Summary for 7K5M
Entry DOI | 10.2210/pdb7k5m/pdb |
Descriptor | Capsid protein, N-(3-chloro-4-fluorophenyl)-3-phenyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide, ISOPROPYL ALCOHOL, ... (4 entities in total) |
Functional Keywords | hvb capsid, viral protein |
Biological source | Hepatitis B virus genotype D subtype adw (isolate United Kingdom/adyw/1979) (HBV-D) |
Total number of polymer chains | 6 |
Total formula weight | 109423.32 |
Authors | Kuduk, S.D.,Stoops, B.,Alexander, R.,Lam, A.M.,Espiritu, C.,Vogel, R.,Lau, V.,Klumpp, K.,Flores, O.A.,Hartman, G.D.,Lukacs, C.M.,Abendroth, J. (deposition date: 2020-09-17, release date: 2021-07-28, Last modification date: 2024-04-03) |
Primary citation | Kuduk, S.D.,Stoops, B.,Alexander, R.,Lam, A.M.,Espiritu, C.,Vogel, R.,Lau, V.,Klumpp, K.,Flores, O.A.,Hartman, G.D. Identification of a new class of HBV capsid assembly modulator. Bioorg.Med.Chem.Lett., 39:127848-127848, 2021 Cited by PubMed: 33610748DOI: 10.1016/j.bmcl.2021.127848 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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