7K45

SARS-CoV-2 spike in complex with the S2E12 neutralizing antibody Fab fragment (local refinement of the RBD and Fab variable domains)

Summary for 7K45

• Entry DOI: 10.2210/pdb7k45/pdb
• EMDB information: 22660
• Descriptor: S2E12 neutralizing antibody Fab fragment (heavy chain), S2E12 neutralizing antibody Fab fragment (light chain), Spike glycoprotein, ... (4 entities in total)
• Functional Keywords: sars-cov-2, covid-19, spike glycoprotein, fusion protein, neutralizing antibodies, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 168058.89

Authors

Tortorici, M.A.,Veesler, D.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-09-14, release date: 2020-10-07, Last modification date: 2023-10-18)

• Primary citation: Tortorici, M.A.,Beltramello, M.,Lempp, F.A.,Pinto, D.,Dang, H.V.,Rosen, L.E.,McCallum, M.,Bowen, J.,Minola, A.,Jaconi, S.,Zatta, F.,De Marco, A.,Guarino, B.,Bianchi, S.,Lauron, E.J.,Tucker, H.,Zhou, J.,Peter, A.,Havenar-Daughton, C.,Wojcechowskyj, J.A.,Case, J.B.,Chen, R.E.,Kaiser, H.,Montiel-Ruiz, M.,Meury, M.,Czudnochowski, N.,Spreafico, R.,Dillen, J.,Ng, C.,Sprugasci, N.,Culap, K.,Benigni, F.,Abdelnabi, R.,Foo, S.C.,Schmid, M.A.,Cameroni, E.,Riva, A.,Gabrieli, A.,Galli, M.,Pizzuto, M.S.,Neyts, J.,Diamond, M.S.,Virgin, H.W.,Snell, G.,Corti, D.,Fink, K.,Veesler, D.; Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms.; Science, 370:950-957, 2020; PubMed: 32972994; DOI: 10.1126/science.abe3354

Experimental method

ELECTRON MICROSCOPY (3.7 Å)